Protein HTRA2

Results of BLAST Screening for sufficient 3D structure homologs in Scratch-1D dataset

Protein ID	Structure	Start	End	E value	Bit score
ENSMLEP00000009226	pdb,3nzi,A,#1	82	292	1.12e-152	100
ENSTBEP00000006597	pdb,3nzi,A,#1	2	211	2.09e-149	99.526
ENSAMEP00000011371	pdb,3nzi,A,#1	139	349	2.47e-149	98.104
ENSLACP00000011379	pdb,3nzi,A,#1	157	367	7.27e-143	94.787
ENSDNOP00000012617	pdb,3nzi,A,#1	210	422	1.76e-142	96.244
ENSONIP00000023991	pdb,3nzi,A,#1	156	366	3.07e-137	90.047
ENSLOCP00000010074	pdb,3nzi,A,#1	172	382	9.85e-136	90.521
ENSPFOP00000026764	pdb,3nzi,A,#1	159	366	1.19e-135	91.827
ENSTNIP00000014844	pdb,3nzi,A,#1	162	372	4.52e-134	89.1
ENSDARP00000048135	pdb,3nzi,A,#1	159	369	7.43e-134	88.626
ENSORLP00000018767	pdb,3nzi,A,#1	156	366	7.49e-134	89.573

Alignment variation features

Conservative sites proportion	Intermediate sites proportion	Variable sites proportion	Conservative sites heterotachy weight	Intermediate sites heterotachy weight	Variable sites heterotachy weight
0.056	0.162	0.782	0.067	0.412	0.521

Site diversity ≤ 0.125	0.125 < Site diversity ≤ 0.25	0.25 < Site diversity ≤ 0.375	0.375 < Site diversity ≤ 0.5	0.5 < Site diversity ≤ 0.625	0.625 < Site diversity ≤ 0.75	0.75 < Site diversity ≤ 0.875	Site diversity > 0.875
0.223744292237443	0.0898021308980213	0.0449010654490107	0.0220700152207002	0.00532724505327245	0.0114155251141553	0.00684931506849315	0.595890410958904

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Predicted (by scratch-1d 1.1) residue solvent accessibilities coding: -5(unknown)=A, 0=R, 5=N, 10=D, 15=C, 20=E, 25=Q, 30=G, 35=H, 40=I, 45=L, 50=K, 55=M, 60=F, 65=P, 70=S, 75=T, 80=W, 85=Y, 90&95=V

Empirical model for relative rates of residue solvent accessibilities changes (in PAML format)

0.427659334 0.000913080 2.256543198 0.003960476 0.255824603 5.383310642 0.098686795 0.314228027 0.768156139 5.794424224 0.000153481 0.066504027 0.166968221 0.684900254 0.758065471 0.333463776 0.368859721 0.146216972 0.945231681 5.942495971 5.519831168 0.000000008 0.042051733 0.089216044 0.305464306 0.419832545 5.964924245 1.075178205 0.008942061 0.033029492 0.021667467 0.058869504 0.419983951 1.378280757 0.704095287 5.656844649 0.000000008 0.014866643 0.059141540 0.159181818 0.198310308 0.269212122 0.227403164 0.869832591 5.393262198 0.000000008 0.035882860 0.176390429 0.038751052 0.233492952 0.496756906 0.109153976 0.107737016 0.761012024 5.818387614 0.000000008 0.020862669 0.031198981 0.000432520 0.123525752 0.164194410 0.085122976 0.387239235 0.522640826 0.425999898 5.733276200 0.000000008 0.050897424 0.000624523 0.116503261 0.093418515 0.118605352 0.226193505 0.155391305 0.492149105 0.694062424 0.742412501 6.906058119 0.000000008 0.004716372 0.136741796 0.001144862 0.100138192 0.008621496 0.199687855 0.143858314 0.145855730 0.404660704 0.735605143 0.773181941 7.186626077 0.000000008 0.129856210 0.000001842 0.051457702 0.270905395 0.283671200 0.090817404 0.005110468 0.661788377 0.045041666 0.162980101 0.468558422 2.475081265 8.882880909 0.000000008 0.034673072 0.151240464 0.303094150 0.000176991 0.599319514 0.177654508 0.248620997 0.028571032 0.410981081 0.032800950 0.337127853 0.119936794 0.560865340 0.037829740 0.000000008 0.000001413 0.067359579 0.000011626 0.049356593 0.073172156 0.037894507 0.051380744 0.346183443 0.576636595 0.457937814 0.000000064 0.139820443 1.796485093 1.420559982 0.389828326 0.000000008 0.000820458 0.088280203 0.010225559 0.000000769 0.071416880 0.744231542 0.398882063 0.244749580 0.000000001 0.000000001 0.205049755 0.201837624 0.230954332 8.974845420 1.667899039 6.338292238 0.000000008 0.000189130 0.167033226 0.000056605 0.538905169 0.004376534 0.332213561 0.000017321 0.027242357 0.828394361 0.014819535 0.727259188 0.010344513 4.373119396 18.841177818 0.000016863 0.538952094 46.888576698 0.156363212 0.013457301 0.013084314 0.000002830 0.416420402 0.027975915 0.354328315 0.131199083 0.400347617 0.235152331 0.805856026 0.294140025 0.129920541 0.469636885 4.130099919 0.940136930 0.000000026 4.600326769 5.265485663 0.013288100 0.140413000 0.083069700 0.071050200 0.072652300 0.080648300 0.078617200 0.074655400 0.086416900 0.080485700 0.071878100 0.061773300 0.038762000 0.020990600 0.004148350 0.004893000 0.003840230 0.003231640 0.002914470 0.006271510