Protein IDH2

Results of BLAST Screening for sufficient 3D structure homologs in Scratch-1D dataset

Protein ID	Structure	Start	End	E value	Bit score
ENSGACP00000014348	pdb,2qfy,B,#1	43	449	0	62.712
ENSCSAVP00000006066	pdb,4l06,C,#1	46	446	0	68.08
ENSAMXP00000007638	pdb,2qfy,E,#1	42	448	0	64.477
ENSGACP00000012105	pdb,4l04,F,#1	5	412	0	81.663
ENSMLEP00000034496	pdb,4l04,D,#1	13	398	0	78.883
ENSOGAP00000020703	pdb,4l03,C,#1	50	451	0	69.975
FBpp0305272	pdb,2qfw,E,#1	72	468	0	63.84
ENSOGAP00000020703	pdb,3inm,B,#1	50	451	0	69.975
ENSMEUP00000009000	pdb,1t09,A,#1	1	410	0	85.266
C34F6.8.1	pdb,4l04,A,#1	33	424	0	66.667
ENSAMXP00000015717	pdb,2qfx,D,#1	10	411	0	64.198

Alignment variation features

Conservative sites proportion	Intermediate sites proportion	Variable sites proportion	Conservative sites heterotachy weight	Intermediate sites heterotachy weight	Variable sites heterotachy weight
0.232	0.367	0.401	0.355	0.188	0.458

Site diversity ≤ 0.125	0.125 < Site diversity ≤ 0.25	0.25 < Site diversity ≤ 0.375	0.375 < Site diversity ≤ 0.5	0.5 < Site diversity ≤ 0.625	0.625 < Site diversity ≤ 0.75	0.75 < Site diversity ≤ 0.875	Site diversity > 0.875
0.528511821974965	0.0458970792767733	0.0111265646731572	0.0361613351877608	0.0125173852573018	0	0	0.365785813630042

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Predicted (by scratch-1d 1.1) residue solvent accessibilities coding: -5(unknown)=A, 0=R, 5=N, 10=D, 15=C, 20=E, 25=Q, 30=G, 35=H, 40=I, 45=L, 50=K, 55=M, 60=F, 65=P, 70=S, 75=T, 80=W, 85=Y, 90&95=V

Empirical model for relative rates of residue solvent accessibilities changes (in PAML format)

1.653542139 0.160218465 1.304046201 0.008083044 0.246885928 3.110565728 0.191604341 0.638094107 0.747201162 4.438188998 0.365522834 0.074888036 0.344232811 1.084296739 1.526350782 0.389903550 0.621874177 0.859088538 1.226937223 5.827804930 5.247498896 0.060297583 0.103433046 0.589045880 0.607493740 1.496176780 6.430745937 2.065592538 0.095027926 0.140319440 0.063022186 1.103453207 0.709294930 1.829682849 0.752873494 6.490424254 0.000000002 0.110179297 0.284183075 0.276849914 0.943322445 0.709549163 0.958260066 1.352554653 6.886817422 0.000000002 0.048508076 0.000058796 0.062463433 0.513469459 0.755331214 1.019701530 1.678660453 2.186953624 7.285020338 0.000000002 0.005369365 0.153562580 0.200492491 0.630736306 0.522827938 0.141728292 0.309685293 1.339424089 2.336790265 7.768511381 0.000000002 0.000000001 0.032054282 0.000001483 0.253457684 0.870877158 0.127624587 0.452515255 0.257994842 0.710643090 3.150345995 11.452119974 0.000000002 0.085073532 0.001255565 0.000168042 0.206139183 0.389980032 0.287253549 0.754653342 0.463753948 1.535238848 1.412752629 3.673859301 13.075755219 0.000000002 0.023457221 0.110346851 0.113816466 0.054726539 0.416847736 0.177832807 0.318635468 0.010239773 0.959121928 0.624077421 0.910036575 3.324015527 10.641278373 0.000000002 0.000000008 0.085019094 0.000000055 0.102060776 0.532525723 0.068712816 0.001334535 0.000298361 0.000086607 0.835120899 1.698070237 3.254634107 3.122691760 12.486323956 0.000000002 0.027812789 0.000000009 0.000000196 0.433730627 0.236130041 0.923084479 0.332423005 0.357128368 1.061951625 1.856833063 0.950779469 1.441651845 3.128082682 3.574282623 19.087500435 0.000000002 0.000002136 0.000000001 0.000000012 0.447442029 0.692995442 0.737730504 0.524766252 0.665104373 0.000076239 0.007930611 1.418025986 0.067382042 0.172749692 0.426734473 19.180759996 28.792422211 0.000000002 0.000000076 0.000000001 0.297600769 0.309078296 0.000000073 0.316912562 0.000000012 0.485660191 0.000016720 0.825385645 0.000002629 4.364006465 3.291709244 1.908581156 0.010878484 9.006702886 35.080154002 0.000000002 0.000000026 0.629120019 1.533533541 1.333780064 0.799514084 0.000008296 0.000024366 0.104362122 1.054177732 0.221830892 0.000001641 1.841486836 3.027851758 2.670222367 3.280561645 32.645240951 2.103952802 0.000004469 0.040445900 0.193589000 0.107366000 0.079717200 0.076257700 0.068159900 0.082460600 0.052032500 0.051761500 0.047595200 0.045145200 0.035434400 0.029574200 0.024856600 0.023380300 0.011494800 0.014173000 0.007659630 0.006149080 0.002746390