Propertites of Heterotachy Phylogeny of MICU2 proteins
Natural logarithm of 'Amino acids -' over 'Residue solvent accessibilities -' based tree branch lengths ratios;
100 iteration of random 50%-alignment jackknife

Inner branch by (daughter) node	Median of branch length from		Mean of logarithmic ratios	Median of logarithmic ratios	Q1 or 25% quantile of logarithmic ratios	Q3 or 75% quantile of logarithmic ratios	Comparing of branch ratios to general population of logarithmic ratios for Inner tree branches
	Amino acids - based tree	Residue solvent accessabilities - based tree					Difference, U-test	Cliff's delta	Normalized p-value, U-test (Holm correction for multiple tests)
N54	2e-06	0.0288	9.62639	10.06610	9.68430	10.32632	Greater	0.95667	3.256e-14
N17	3e-06	0.11453	8.55328	10.51311	5.58600	11.39992	Greater	0.87953	3.256e-14
N19	0.004455	0.390428	4.08137	4.09244	3.63812	4.59061	Greater	0.84851	3.256e-14
N28	0.053789	1.136852	3.04193	3.05671	2.63105	3.48827	Greater	0.76898	3.256e-14
N148	0.018817	0.281274	2.67070	2.60545	2.24451	3.03512	Greater	0.73385	3.256e-14
N114	0.004969	0.11367	2.60727	2.67039	2.09578	3.21439	Greater	0.70828	3.256e-14
N43	0.000374	0.049812	5.17519	4.87171	2.44399	9.86259	Greater	0.69218	3.256e-14
N32	0.010686	0.151143	2.41701	2.38709	1.90975	2.87961	Greater	0.67978	3.256e-14
N97	0.014395	0.146179	2.43945	2.40470	1.89225	2.91186	Greater	0.67965	3.256e-14
N22	0.005184	0.094173	2.49180	2.52595	2.03071	3.06452	Greater	0.67919	3.256e-14
N120	0.007739	0.045905	4.98517	2.24839	1.21883	9.88252	Greater	0.63501	3.256e-14
N51	2e-06	0.018218	6.02300	8.51579	0.40547	9.69614	Greater	0.62396	3.256e-14
N44	0.017008	0.128781	2.32432	2.08070	1.56608	2.70145	Greater	0.61321	3.256e-14
N59	0.010641	0.083539	2.08451	2.05784	1.57866	2.63460	Greater	0.60907	3.256e-14
N119	0.008888	0.076204	2.03987	2.07908	1.57510	2.60567	Greater	0.59828	3.256e-14
N143	0.00229	0.041884	3.71943	2.46371	1.32623	7.83834	Greater	0.59548	3.256e-14
N111	0.015811	0.071841	1.85597	1.85276	1.37935	2.40777	Greater	0.55417	3.256e-14
N117	2e-06	0.013538	5.04293	8.07714	0.69315	9.78042	Greater	0.53701	3.256e-14
N50	0.004016	0.009757	3.27162	2.34937	1.35682	8.50896	Greater	0.53307	3.256e-14
N70	0.049231	0.211028	1.68072	1.60244	1.26844	1.98613	Greater	0.52881	3.256e-14
N45	0.554212	2.529628	1.60076	1.60168	1.43722	1.76494	Greater	0.52637	3.256e-14
N83	0.078183	0.272091	1.66080	1.62722	1.15488	2.09691	Greater	0.51939	3.256e-14
N136	0.022432	0.127104	1.62331	1.62350	1.27019	1.96966	Greater	0.51427	3.256e-14
N124	0.025726	0.108704	1.64256	1.61503	1.20581	2.04341	Greater	0.51379	3.256e-14
N16	0.07179	0.373666	1.60290	1.57461	1.15270	2.06602	Greater	0.50647	3.256e-14
N140	0.007462	0.046199	1.93970	1.89712	1.18716	2.50425	Greater	0.49373	3.256e-14
N67	0.016194	0.068232	3.77412	1.34023	0.70048	9.85061	Greater	0.49311	3.256e-14
N2	3e-06	7.8e-05	3.34233	3.21888	0.40547	7.85813	Greater	0.48004	3.256e-14
N103	0.036613	0.170099	1.53835	1.58496	1.10095	2.01474	Greater	0.47084	3.256e-14
N138	0.012275	0.059953	1.57945	1.54256	0.97666	2.17023	Greater	0.45152	3.256e-14
N118	0.007736	0.065475	1.62221	1.87535	0.93397	2.52731	Greater	0.44902	3.256e-14
N30	3e-06	0.08494	3.94178	2.98557	0.10107	10.23468	Greater	0.44267	3.256e-14
N52	3e-06	3e-06	4.14964	0.40547	0.00000	8.50238	Greater	0.41592	3.256e-14
N122	0.038452	0.112203	1.23511	1.22507	0.93516	1.52607	Greater	0.40363	3.256e-14
N24	3e-06	1.4e-05	1.51414	1.79176	0.40547	2.39790	Greater	0.36465	3.256e-14
N130	0.013258	0.036493	1.01041	1.18164	0.56720	1.71906	Greater	0.31307	3.256e-14
N139	0.020628	0.046907	1.00715	1.03657	0.48613	1.54834	Greater	0.30236	3.256e-14
N85	0.032399	0.093103	1.03618	1.10825	0.39389	1.69890	Greater	0.29894	3.256e-14
N34	0.064919	0.186441	0.97761	1.06002	0.42799	1.52471	Greater	0.29818	3.256e-14
N126	0.023226	0.044459	0.97236	1.03137	0.49339	1.49389	Greater	0.29382	3.256e-14
N7	0.003615	0.005035	2.63997	2.46253	-1.22018	7.95805	Greater	0.29149	3.256e-14
N110	0.028562	0.072746	0.93605	1.01295	0.54876	1.49187	Greater	0.28796	3.256e-14
N46	0.023292	0.081851	0.97228	1.13491	0.35717	1.68402	Greater	0.28298	3.256e-14
N145	0.012185	0.024994	0.86042	0.98434	0.38068	1.51350	Greater	0.26013	3.256e-14
N142	0.033595	0.064225	0.83326	0.82494	0.49019	1.18057	Greater	0.25856	3.256e-14
N92	0.059568	0.150739	0.90593	0.78839	0.25984	1.38862	Greater	0.25150	3.256e-14
N129	0.020807	0.054587	0.66271	1.27648	-0.17351	1.93938	Greater	0.23308	3.256e-14
N29	0.056213	0.123328	0.94067	0.74234	-0.02103	1.90967	Greater	0.22466	3.256e-14
N60	0.025277	0.052572	0.77939	0.77973	0.22348	1.34475	Greater	0.22237	3.256e-14
N9	0.015698	0.080778	0.76923	0.89756	-0.21491	1.89799	Greater	0.20448	3.256e-14
N93	0.04213	0.118486	0.75363	0.75847	-0.11000	1.62288	Greater	0.19671	3.256e-14
N79	0.135762	0.243232	0.86290	0.80690	-0.40000	1.78963	Greater	0.18329	3.256e-14
N116	0.004495	4.4e-05	0.95384	1.68470	-4.12854	3.44999	Greater	0.17575	3.256e-14
N100	0.036781	0.092774	0.68065	0.66901	-0.33132	1.81445	Greater	0.17236	3.256e-14
N3	0.029147	0.075224	0.80748	0.71590	-0.64603	2.49144	Greater	0.16586	3.256e-14
N73	0.047833	0.082117	0.59648	0.60527	0.19351	1.00821	Greater	0.16319	3.256e-14
N61	0.01479	0.021253	0.50147	0.66828	-0.11537	1.33135	Greater	0.14721	5.3376e-14
N74	0.097752	0.183502	0.51049	0.52136	0.22028	0.81658	Greater	0.13570	3.256e-14
N128	0.005132	0.006931	1.00965	0.69971	-1.15424	4.90527	Greater	0.12664	4.302e-13
N64	0.019788	0.027635	0.54848	0.46049	-0.15452	1.14029	Greater	0.12141	8.2525e-11
N13	0.112429	0.127908	0.51520	0.39795	-0.09547	1.06196	Greater	0.11890	1.31544e-11
N104	0.14148	0.233881	0.46387	0.48346	0.10082	0.86283	Greater	0.11479	7.4007e-11
N15	0.075763	0.132507	0.44869	0.44894	-0.11013	1.03321	Greater	0.10707	1.55544e-09
N127	0.014918	0.027691	-0.07706	0.67547	-0.71960	1.37309	Greater	0.06590	0.00096178
N63	0.081391	0.108301	0.32894	0.34781	0.06418	0.61427	Greater	0.06171	0.0019008
N27	3e-06	6e-06	0.20590	0.38667	-4.85203	2.56732	Greater	0.05689	0.0053941
N62	0.030509	0.0451	0.27568	0.38404	-0.20705	0.90329	Greater	0.05538	0.0074985
N134	0.009127	0.019666	-0.01772	0.55086	-0.59737	1.24101	Greater	0.05313	0.016308
N82	0.243864	0.348091	0.30691	0.28782	0.06561	0.53197	Greater	0.05203	0.0124936
N146	0.008511	0.000377	0.62658	0.22139	-1.62941	1.54045	Greater	0.02914	0.4008
N98	0.052645	0.059009	0.16150	0.28503	-0.39118	0.87171	Greater	0.01455	0.956
N77	0.067202	0.115929	0.08897	0.13790	-0.73249	1.06862	Greater	0.01023	1
N49	2e-06	2e-06	-0.21608	0.69315	-5.31567	0.69315	Greater	0.00225	1
N18	0.009624	0.00702	-0.84430	0.47975	-5.14689	2.03255	Greater	0.00198	1
N71	0.143617	0.150201	0.16434	0.17428	-0.06601	0.40286	Lesser	-0.00894	1
N65	0.040272	0.040891	0.08878	0.14174	-0.40467	0.65018	Lesser	-0.01807	0.8796
N76	0.215211	0.209041	0.14783	0.04886	-0.40778	0.57294	Lesser	-0.01975	0.8421
N36	0.116741	0.119425	0.10410	-0.06696	-0.70241	0.95355	Lesser	-0.02444	0.58552
N90	0.104383	0.117771	0.08824	0.13752	-0.31201	0.56520	Lesser	-0.02792	0.42156
N87	0.230119	0.249333	0.02761	0.04230	-0.50572	0.63374	Lesser	-0.04788	0.024409
N10	0.033752	9.5e-05	-0.06043	-1.12041	-4.00232	5.43590	Lesser	-0.05126	0.013559
N40	0.062176	0.068886	-0.10755	-0.04182	-0.86484	0.71938	Lesser	-0.05843	0.0070048
N105	0.145751	0.139981	0.00231	0.03226	-0.28727	0.34353	Lesser	-0.07124	0.00018882
N137	0.035849	0.028084	-0.15117	0.02346	-0.61324	0.56998	Lesser	-0.08323	9.6054e-06
N80	1.118172	0.92215	-0.03474	-0.04482	-0.31870	0.23674	Lesser	-0.09397	1.84426e-07
N35	0.045286	0.038212	-0.21978	-0.15224	-1.02253	0.72725	Lesser	-0.09881	4.968e-08
N41	0.097825	0.050142	-0.31593	-0.14116	-0.91910	0.54884	Lesser	-0.12067	7.4007e-11
N89	0.018016	0.018433	-0.70495	-0.05004	-2.00032	0.84324	Lesser	-0.12214	5.9276e-12
N57	0.080175	0.065824	-0.23685	-0.08445	-0.64493	0.33376	Lesser	-0.13451	1.43809e-13
N58	0.07307	0.051721	-0.19415	-0.14271	-0.51699	0.19042	Lesser	-0.14269	3.256e-14
N66	0.022009	0.021762	-0.75332	-0.11436	-1.13101	0.53021	Lesser	-0.14981	3.256e-14
N48	3e-06	2e-06	-0.68365	-0.40547	-4.26970	0.00000	Lesser	-0.15443	3.256e-14
N113	0.044243	0.035031	-0.45739	-0.12689	-1.01194	0.39201	Lesser	-0.15492	3.256e-14
N55	0.007166	3e-06	-1.19248	0.00000	-7.27078	0.40547	Lesser	-0.17573	3.256e-14
N1	0.196154	0.117019	-0.34865	-0.26957	-0.71087	0.10165	Lesser	-0.18956	3.256e-14
N56	0.105081	0.091917	-0.28715	-0.27743	-0.57974	0.02611	Lesser	-0.19023	3.256e-14
N131	0.008667	0.001285	-0.86563	-1.15085	-2.76403	0.83251	Lesser	-0.20238	3.256e-14
N20	0.021288	0.013188	-0.85169	-0.34375	-1.45698	0.41468	Lesser	-0.20638	3.256e-14
N115	0.044683	0.031742	-0.93670	-0.28280	-1.52683	0.41308	Lesser	-0.20850	3.256e-14
N112	0.008199	4.5e-05	-1.44796	-2.40514	-5.24276	1.53354	Lesser	-0.20901	3.256e-14
N53	0.007672	2e-06	-1.90517	0.00000	-8.22081	0.69315	Lesser	-0.22136	3.256e-14
N144	0.096992	0.088541	-0.59428	-0.35736	-1.20139	0.25001	Lesser	-0.22215	3.256e-14
N6	0.207696	0.129298	-0.49560	-0.46727	-0.94312	0.02565	Lesser	-0.23164	3.256e-14
N69	0.074893	0.064125	-0.50915	-0.42560	-0.87442	-0.01787	Lesser	-0.23844	3.256e-14
N26	0.009739	0.000353	-2.03941	-1.71297	-6.49534	1.84583	Lesser	-0.24092	3.256e-14
N95	0.2487	0.127984	-0.49383	-0.41575	-0.84182	-0.05005	Lesser	-0.24654	3.256e-14
N121	0.014859	0.007734	-1.86450	-0.42446	-8.15249	0.46122	Lesser	-0.25880	3.256e-14
N99	0.192456	0.104359	-0.59806	-0.58791	-1.03495	-0.13930	Lesser	-0.27190	3.256e-14
N47	0.019192	0.004697	-2.39663	-0.66474	-8.28307	0.71423	Lesser	-0.27208	3.256e-14
N141	0.010303	0.00373	-2.16619	-0.85515	-5.69306	0.71355	Lesser	-0.28265	3.256e-14
N14	0.059951	0.02087	-0.82148	-0.60673	-1.44842	-0.01531	Lesser	-0.28463	3.256e-14
N21	0.010188	2.9e-05	-2.28656	-3.70577	-6.54832	1.50408	Lesser	-0.29366	3.256e-14
N37	0.351618	0.181861	-0.63727	-0.64759	-0.90109	-0.36866	Lesser	-0.31466	3.256e-14
N132	0.01307	0.000465	-1.88926	-2.46467	-5.07699	0.49354	Lesser	-0.31618	3.256e-14
N107	0.020204	0.001414	-1.70690	-1.13026	-4.84225	0.18422	Lesser	-0.32143	3.256e-14
N8	0.042004	0.026564	-1.02973	-0.87684	-1.62296	-0.21021	Lesser	-0.34209	3.256e-14
N5	0.174298	0.063298	-1.06558	-0.89164	-1.50421	-0.34464	Lesser	-0.36416	3.256e-14
N91	0.157725	0.037707	-1.13872	-1.06261	-1.63337	-0.55251	Lesser	-0.39981	3.256e-14
N25	0.008485	0.001243	-2.89933	-2.74071	-6.98224	0.00000	Lesser	-0.41659	3.256e-14
N123	0.024113	0.00558	-2.53429	-2.36712	-5.39363	0.09615	Lesser	-0.42761	3.256e-14
N135	0.009488	0.000991	-2.15526	-2.41300	-4.60433	-1.18072	Lesser	-0.42855	3.256e-14
N81	0.026607	0.008197	-2.24527	-2.06952	-3.76114	-0.34627	Lesser	-0.43074	3.256e-14
N94	0.287842	0.084174	-1.38472	-1.17628	-1.86793	-0.62147	Lesser	-0.43260	3.256e-14
N96	0.090268	0.040931	-1.94002	-1.38234	-3.08312	-0.51764	Lesser	-0.43884	3.256e-14
N102	0.209058	0.049978	-1.76794	-1.19756	-2.55879	-0.51234	Lesser	-0.44331	3.256e-14
N101	0.185726	0.046666	-1.60837	-1.52144	-2.23913	-0.82713	Lesser	-0.45214	3.256e-14
N11	0.125929	0.021343	-1.77150	-1.48045	-2.37585	-0.80725	Lesser	-0.46476	3.256e-14
N125	0.037392	0.003246	-2.25314	-1.65876	-3.75859	-0.52405	Lesser	-0.47343	3.256e-14
N84	0.098261	0.035287	-2.69190	-1.48843	-5.56881	-0.41965	Lesser	-0.47942	3.256e-14
N42	0.867006	0.200838	-1.60864	-1.55200	-1.98670	-1.16513	Lesser	-0.52153	3.256e-14
N78	0.17869	0.010333	-2.38796	-1.68596	-3.78606	-0.90281	Lesser	-0.52182	3.256e-14
N4	0.025952	0.000234	-3.69131	-4.24850	-5.95231	-1.86517	Lesser	-0.52393	3.256e-14
N86	0.252999	0.036432	-2.81298	-2.31918	-4.60128	-0.81391	Lesser	-0.53026	3.256e-14
N147	0.013178	0.000707	-3.41118	-4.10241	-5.64612	-1.86178	Lesser	-0.54838	3.256e-14
N133	0.075265	0.000694	-3.55313	-4.19982	-6.08901	-1.43550	Lesser	-0.56333	3.256e-14
N75	0.047095	0.002403	-3.14761	-2.47859	-5.16395	-0.88792	Lesser	-0.56865	3.256e-14
N33	0.274385	0.011344	-3.59034	-2.95716	-6.29990	-1.65312	Lesser	-0.57949	3.256e-14
N38	0.410115	0.020038	-3.77249	-3.15858	-5.81117	-1.19344	Lesser	-0.62520	3.256e-14
N106	0.054672	5.6e-05	-4.71120	-6.37411	-7.37765	-1.29949	Lesser	-0.63246	3.256e-14
N72	0.093092	0.018052	-4.34368	-2.28331	-8.18884	-1.29499	Lesser	-0.66382	3.256e-14
N12	0.014835	3e-05	-4.52144	-4.51921	-6.01353	-2.81081	Lesser	-0.68765	3.256e-14
N23	0.012184	2.1e-05	-5.12576	-6.17113	-7.19868	-3.54856	Lesser	-0.69238	3.256e-14
N108	0.020218	7.7e-05	-5.41397	-5.91376	-6.55784	-3.90895	Lesser	-0.78443	3.256e-14
N109	0.071511	0.00012	-5.46943	-6.21790	-6.84073	-3.83620	Lesser	-0.79520	3.256e-14
N88	0.196088	0.000497	-5.47501	-5.65568	-6.33364	-4.34104	Lesser	-0.80013	3.256e-14
N39	0.14879	0.000462	-6.60242	-6.09532	-7.05359	-5.16658	Lesser	-0.84467	3.256e-14
N68	0.047626	3e-06	-7.60564	-9.50196	-10.04640	-5.27686	Lesser	-0.86133	3.256e-14
N31	0.195938	3e-06	-9.18904	-10.72369	-11.45444	-6.61538	Lesser	-0.92995	3.256e-14